The immune system regulates arguably all physiological processes, and proper immune function is essential for maintaining health and preventing disease. Our lab seeks to define how immune responses are orchestrated across diverse physiological and pathological contexts, with particular emphasis on infection, reproduction, allergy, and cancer. We combine mechanistic studies of cellular and molecular immune effector molecules and pathways with animal models of diseases and analyses of human cohorts to interrogate immune function across experimental systems and clinical settings. Through this integrative approach, we aim to uncover conserved and context-specific principles that govern immune regulation, and to understand how these principles are adapted or disrupted in health and disease.

A focus of our recent work has been to elucidate the mechanisms that control the generation, diversification, and function of systemic and mucosal antibody responses. These processes are critical for protective immunity against pathogens and for maintaining barrier integrity at mucosal surfaces. We have identified key regulatory pathways that shape antibody production, class switching, and repertoire diversity, providing insight into how effective and durable humoral immunity is established and maintained.

In parallel, we investigate immune regulation of developmental and reproductive processes. Our studies have revealed previously underappreciated roles for certain immune cells, such as B lymphocytes, in supporting maternal-fetal tolerance and promoting pregnancy to term. We have also begun to define how dysregulation of these immune processes contributes to adverse reproductive outcomes, including preterm birth and pregnancy complications.

Together, our work aims to bridge immunobiology with clinical translation by uncovering how immune regulation is adapted to distinct physiological environments. Ultimately, we seek to leverage these insights to inform new strategies for preventing and treating immune-mediated diseases, improving maternal, fetal and infant health, and enhancing protective immunity in children and adults.