Selected Publications »
Reproduction and immunology
- Zhou JZ, Way SS, Chen K (2018). Immunology of the uterine and vaginal mucosae. Trends in Immunology 39: 302-314.
- Huang B, Faucette AN, Pawlitz MD, Pei B, Goyert JW, Zheng JZ, El-Hage NG, Cols M, Lin J, Yao F, Jassal JS, Dewar RS III, Dai J, Shen C, Polin LA, Nichols RA, Jones TB, Deng J, Bluth MH, Puder KS, Gonik B, Nayak NR, Puscheck E, Wei W-Z, Cerutti A, Colonna M, Chen K (2017). Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. Nature Medicine 23:128-135.
- Faucette AN, Unger BL, Gonik B, Chen K (2015). Maternal vaccination: moving the science forward. Human Reproduction Update 21:119-135.
Humoral immunity, mucosal immunity and immunodeficiency
- Chen K, Hao Y, Guzman M, Li G, Cerutti A (2023). Antibody mediated regulation of basophils: emerging views and clinical implications. Trends in Immunology (in press).
- Chen K, Giuliana M, Grasset E, Cerutti A (2020). Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA. Nature Reviews Immunology 20:427-441.
- Shan M, Carillo J, Yeste A, Gutzeit C, Garzon DS, Pybus M, Grasset EK, Yeiser JR, Matthews DB, van de Veen W, Comerma L, He B, Boonpiyathad T, Lee H, Blanco J, Osborne LC, Siracusa MC, Akdis M, Artis D, Mehandru S, Sampson HA, Berin MC, Chen K, Cerutti A (2018). Secreted IgD Amplifies Humoral T helper 2 responses by Activating Basophils through Galectin-9 and CD44. Immunity 49:709-724.
- Siriwardena S, Chen K, Bhagwat AS (2016). Functions and malfunctions of mammalian DNA-cytosine deaminases. Chemical Reviews 116:12688–12710.
- Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comera L, Huang B, Blander JM, Xiong H, Meyer L, Berin C, Augenlicht LH, Velcich A, Cerutti A (2013). Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342:447-453.
- Puga I, Cols M, Barra CM, He B, Cassis L, Gentile M, Comerma L, Chorny A, Shan M, Xu W, Magri G, Knowles DM, Tam W, Chiu A, Bussel JB, Serrano S, Lorente JA, Bellosillo B, Lloreta J, Juanpere N, Alameda F, Baró T, de Heredia CD, Torán N, Català A, Torrebadell M, Fortuny C, Cusí V, Carreras C, Diaz GA, Blander JM, Farber CM, Silvestri G, Cunningham-Rundles C, Calvillo M, Dufour C, Notarangelo LD, Lougaris V, Plebani A, Casanova JL, Ganal SC, Diefenbach A, Aróstegui JI, Juan M, Yagüe J, Mahlaoui N, Donadieu J, Chen K, Cerutti A (2012). B cell-helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen. Nature Immunology 13:170-180 (cover story).
- Chen K, Cerutti A (2011). The function and regulation of Immunoglobulin D. Current Opinion in Immunology 23:345-352.
- Cerutti A, Chen K, Chorny A (2011). Immunoglobulin responses at mucosal interfaces. Annual Review of Immunology 29:273-293.
- Chen K, Cerutti A (2011). AIDing the pursuit of IgA diversity. Nature Immunology 12:197-198.
- Chen K, Cerutti A (2010). Vaccination strategies to promote mucosal antibody responses. Immunity 33:479-491.
- He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel J B, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova J-L, Cerutti A (2010). The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nature Immunology 11: 836-845.
- Chen K, Cerutti A (2010). New Insights into the enigma of immunoglobulin D. Immunological Reviews 237:160-179.
- Chen K, Xu W, Wilson M, He B, Miller NW, Bengten E, Edholm E-S, Santini PA, Rath P, Chiu A, Cattalini M, Litzman J, Bussel J, Huang B, Meini A, Riesbeck K, Cunningham-Rundles C, Plebani A, Cerutti A (2009). Immunoglobulin D enhances immune surveillance by activating antimicrobial, pro-inflammatory and B-cell stimulating programs in basophils. Nature Immunology 10:889-898.
- Xu W, Santini PA, Sullivan JS, He B, Shan M, Ball SC, Dyer WB, Ketas TJ, Chadburn A, Cohen-Gould L, Knowles DM, Chiu A, Sanders RW, Chen K, Cerutti A (2009). HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nature Immunology 10:1008-1017 (cover story).
Cancer immunotherapy
- Sheng S, Bernardo M, Dzinic SH, Chen K, Sakr WA (2022). The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin. Journal for ImmunoTherapy of Cancer 41:965-974.
- Chen YQ, Li PC, Pan N, Gao R, Wen ZF, Zhang TY, Huang F, Wu FY, Ou XL, Zhang JP, Zhu XJ, Hu HM, Chen K, Cai Y-L, Wang L-X (2019). Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2–IL-6 cascade. Journal for ImmunoTherapy of Cancer 7:178.
- Dzinic SH, Bernardo MM, Li X, Fernandez-Valdivia R, Ho Y-S, Mi Q-S, Bandyopadhyay S, Lonardo F, Vranic S, Oliveira DSM, Bonfil RD, Dyson G, Chen K, Omerovic A, Sheng X, Han X, Wu D, Bi X, Cabaravdic D, Jakupovic U, Wahba M, Pang A, Harajli D, Sakr WA, Sheng S (2017). An essential role of maspin in embryogenesis and tumor suppression. Cancer Research 77:886-896.
- Huang B, Yin M, Li X, Cao G, Qi J, Lou G, Sheng S, Kou J*, Chen K*, Yu B (2016). Migration-Inducing Protein 7 promotes epithelial ovarian cancer tumorigenesis and angiogenesis and independently predicts poor prognosis. Oncotarget 7:27552-27566.
- Kathawala RJ, Sodani K, Chen K, Patel A, Abuznait AH, Anreddy N, Kaddoumi A, Ashby CR Jr, Chen Z-S (2014). Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study. Molecular Cancer Therapeutics 13:714-723.
- Hong P, Chen K, Huang B, Liu M, Li Z, Cui M, Chaqour B, Pan X, Barton ER, Jiang X-C, Siddiqui MAQ (2012). HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration. Journal of Clinical Investigation 122:3873-3887.
- Cols M, Barra CM, He B, Puga I, Xu W, Chiu A, Tam W, Knowles DM, Dillon SR, Leonard JP, Chen K, Cerutti A (2012). Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related molecules BAFF, APRIL and CD40L. Journal of Immunology 188:6071-6083.
- Huang B, Deora A, He K-L, Chen K, Sui G, Almeida D, Jacovina A, Greenberg C, Hajjar KA (2011). Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice. Blood 118:2918-2929.
- Ballon G, Chen K, Perez R, Tam W, Cesarman E (2011). Kaposi Sarcoma Herpesvirus (KSHV) vFLIP oncoprotein induces B-cell transdifferentiation and tumorigenesis in mice. Journal of Clinical Investigation 121:1141-1153 (cover story).
Book Chapters »
- Cerutti A, Chen K (2010). Role of BAFF and APRIL in antibody production and diversification. In “Blys Ligands and Receptors”, Humana Press, NJ, USA.
- Cerutti A, Chen K (2010). IgAのクラススイッチ機構 (IgA isotype class switching). In “Clinical Mucosal Immunology”, Synergy International Inc., Tokyo, Japan.
- Translated into Japanese and used as a textbook for medical students in Japan.
Patents »
- Chen K, Pei B. New methods for the generation of therapeutic, diagnostic and research antibodies. US patent application No.: 62552292. Filed on August 30, 2017.
- Chen K. New methods for the treatment and prevention of preterm labor. US patent application No.: 62381964. Filed on August 31, 2016.
- Cerutti A, Chen K. Methods for treating IgE-mediated disorder. International application No.: PCT/US2010/029541. Issued on September 9, 2014.
